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Abstract Synaptic aging is a core manifestation of brain aging arising from the convergence of fundamental biological aging processes, including genomic instability, loss of proteostasis, mitochondrial dysfunction, oxidative stress, and chronic low-grade inflammation

It is a ghrelin receptor agonist, a growth hormone secretagogue

doi:10.1017/S0007114512005429 Donohue TM, Osna NA, Clemens DL (2006) Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity