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In contrast, when brain triculture was directly introduced to PBDE in 2D experiments, there was a significant shift to a pro-inflammatory environment (GM-CSF ( p = 0.01 ), IL-8 ( p = 0.04 ) and TNF-alpha ( p = 0.03 ) that was not observed on-chip (Figure 5)

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To differentiate between bacterial killing and metabolic slowdown as the cause of reduced CFU counts in the metZ strain at pH 5.5 (Supplementary Fig

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310 (2), H153H173

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