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5.3 Renal Impairment and Bleeding Risk in Adult Patients Fondaparinux sodium increases the risk of bleeding in adult patients with impaired renal function due to reduced clearance [see Clinical Pharmacology (12.4)]

S5A, B), indicating that Golgi retention is not solely dependent on this region

Those Chi 131153 ab-positive aggregates were not stained with a G127X-mutant specific antibody directed to the non-native, C-terminal sequence of the five amino acids, suggesting pathological aggregation of wild-type SOD1 that is not co-localized with G127X-mutant proteins

(C,D) CL1-5 cells not exposed to radiation (C) or exposed to radiation at 24 hr (D)

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