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355 Moreover, TDP-43 aggregates can translocate into mitochondria, triggering mitochondrial DNA release into the cytoplasm and activating inflammatory signaling through the cGAS-STING pathway

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In turn, this promotes apoptosis (cell death) in muscle cells

These results were deemed correlated to the increased concentration of the lipolytic 3-AR receptors, indicating the peptides may work via the beta-adrenergic pathway

Peiyu et al., 2023)

Types of nuclear localization signals and mechanisms of protein import into the nucleus