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Iacobini M, Menichelli A, Palumbo G, Multari G, Werner B, Del Principe D

The higher dose (50 mg/kg) of MB effectively restored liver function markers, antioxidant status, hindered apoptosis and regulated iron regulatory proteins (ferritin and NCOA4 that reflects ferritinophagy) to levels comparable with the control group

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Insulin-like growth factor-1, as discussed earlier, has implications on lipid and glucose metabolism [87, 88], and its exogenous administration enhances insulin sensitivity in healthy adults [139, 140] as well as those with T2D [155]

It plays a central role in cellular bioenergetics, providing ATP through OXPHOS and supporting macromolecular biosynthesis, including nucleotides, lipids, heme, and iron-sulfur clusters [156]

J Clin Oncol 4(4):489-95, 1986