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Silibinin has been proven to inhibit the upregulation of co-stimulatory molecules and major histocompatibility complex (MHC) class II molecules on lipopolysaccharide (LPS) stimulated mature DCs, while also suppressing the release of pro-inflammatory cytokines IL-12, IL-23, and TNF-, as well as CD4 + T cell proliferation and Th1/Th17 function, indicating strong immunosuppressive activity (112)

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The Table 1 presents a comprehensive summary of the specific effects of high-altitude environments on different aspects of the male reproductive system, along with relevant research cases that support these findings

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To view a copy of this license, visit About this article Cite this article Wang, J., Zhou, Y., Zhang, H

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