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This is because B12 helps produce serotonin, a neurotransmitter that regulates mood and emotions

10.1016/j.ccell.2018.03.004 125 ToumiR.SamerA.SoufliI.RafaH.Touil-BoukoffaC

The synergy becomes clear: AOD-9604 mobilises fat, but that mobilisation is wasted if mitochondria lack the NAD+ cofactors required to oxidise fatty acids through beta-oxidation and the Krebs cycle

Holmes AS, Blaxill MF, Haley BE: Reduced Levels of Mercury in First Baby Haircuts of Autistic Children

For the purpose of anti-aging therapy (with no surgical adjunct), I typically place patients on one IV infusion monthly, maybe a few times the first month, and then encourage subcutaneous doses weekly or every two weeks in between

They're considered to be weak, so they're usually given along with other types of diuretics