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Lipid peroxidation generates hydroperoxides as well as endoperoxides, which undergo fragmentation to produce a broad range of reactive intermediates called reactive carbonyl species (RCS) such as isoprostanes (IsoPs), neuroprotanes, malondialdehyde, unsaturated aldehydes including 4-hydroxy-2- trans -nonenal (HNE), 4-hydroxy-2- trans -hexenal (HHE), and 2-propenal (acrolein), with different degrees of reactivity (Porter et al., 1995

For example, octanal is present in mouse and human plasma and increases with a high-fat diet

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Hauser DN, Hastings TG

Ferroptosis suppressor protein-1 (FSP1) is an oxidoreductase that reduces ubiquinone (CoQ) to ubiquinol (CoQH 2 ) [16, 17] or reduces oxidized hydroxyoestradiols [18]