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We look at studies to find the best dose for them

Mitiperstat exhibits a weak inhibitory activity against 50 CYP3A4 with an IC of 6 M

Besides, two nitroimidazoles (Koike et al., 2020), itraconazole (Xu et al., 2021), and dichloroacetate (Sun et al., 2021) are also proven to have therapeutic potential through promoting ferroptosis in CSCs

Interestingly, immunofluorescence staining revealed profound F-actin contraction in glucose-deprived shGDH1 cells, which could be rescued by TCEP (Supplementary Fig

Dosing protocols from preclinical research Since FTPP has no approved human dosing and the Phase 1 trial data was never published, all dosing information comes from animal studies