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The clear behavioral differences (for example, women are more likely to be depressed than men) were thought to be explained by non-physiological causes better left to social scientists

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Notably, experimental evidence demonstrates that DAB2IP linearly inhibits both the JAK2/STAT and PI3K/Akt pathways, an integrated model further proposes the existence of significant crosstalk between these pathways, potentially forming a feed-forward loop that amplifies the dysfunction of VSMCs (33)

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DOI: 10.1007/978-3-319-04990-8 97