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Clinical studies in non-diabetic cohorts have demonstrated modest vascular and myocardial improvements, but findings remain variable and definitive cardiovascular outcomes trials are still lacking (Lexis et al., 2014

For the intracellular metabolomic analysis, cells were quickly washed for three times with PBS to remove contaminations from the media

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Wang L, Almeida LEF, Spornick NA, Kenyon N, Kamimura S, Khaibullina A, Nouraie M, Quezado ZMN (2015) Modulation of social deficits and repetitive behaviors in a mouse model of autism: the role of the nicotinic cholinergic system

A cohort study from the Nurses Health Study II reinforced these findings, showing that higher total fibre intake was associated with a decreased incidence of GERD symptoms, with the strongest associations observed for fibre from fruits and vegetables, but not from cereals (Reference Samuthpongtorn, Mehta and Ma78)

-Tocopherol was also linked to lower NFT accumulation in brain regions affected in early Braak stages, such as the hippocampus, amygdala, and entorhinal cortex but not in the later-affected brain regions [12] In APOE4 carriers (i.e., individuals with at least one copy of the 4 allele of the apolipoprotein E (APOE) gene, a well-established genetic risk factor for late-onset AD), higher dietary intake of -tocopherol was significantly associated with a slower rate of cognitive decline [46]