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The therapeutic outcome is determined by what happens during the activation window, not how long the peptide remains detectable

Tiwari et al

All peptides used in this study except rat amylin purchased from Bachem and Pramlintide purchased from Millipore Sigma were HPLC-purified with at least 85% purity by Genscript (Piscataway, NJ) or Biomatik (Wilmington, Delaware, USA)

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Carbamazepine alleviates retinal and optic nerve neural degeneration in diabetic mice via nerve growth factor-induced PI3K/Akt/mTOR activation

Fig 5A)