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This result is relevant since it is known that this transition underlies corneal scarring and opacification, which can be symptomatic in patients chronically afflicted with stromal infection

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10.1159/000516396 144 LiuQ.WangJ.GuZ.OuyangT.GaoH.KanH.et al (2024)

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We determined an optimal celastrol dose of 1 mg/kg/day in vivo for DKD mice and that celastrol exhibited efficacy comparable to losartan potassium in treating db/db mice

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