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Weber YG, Biskup S, Helbig KL, Von Spiczak S, Lerche H (2017) The role of genetic testing in epilepsy diagnosis and management

Unlike medications that temporarily mask discomfort, prolotherapy works to restore tissue integrity, offering the potential for longer-lasting relief and improved function

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Furthermore, the threshold effect is consistent with the concept that methionine synthase activity may become saturated beyond a certain B12 concentration [17], explaining the diminishing returns observed at higher levels