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doi: 10.1093/ckj/sfab169 20

Profound sedation, respiratory depression, coma, and death may result from the concomitant use of hydrocodone bitartrate and acetaminophen tablets with benzodiazepines and/or other CNS depressants, including alcohol [e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids]

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Analysis of her liver function showed a total bilirubin level of 101.1 mol/L (017.0 mol/L), direct bilirubin level of 10.3 mol/L (08.0 mol/L), reticulocyte count of 10.42% (2.0%6.0%), and she was negative in the Coombs test

Sometimes it can be an early clue to a hepatic, renal, hematologic, inflammatory, or malignant process