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Furthermore, genetically engineered mouse models revealed that tumor cells and cDC1s compete for glutamine uptake through SLC38A2 to regulate antitumor immunity [47]

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In the same year, a clinical study by Igarashi M and colleagues at the University of Tokyo in Japan showed that the oral administration of 250 mg/d NMN for 12 weeks was safe and well-tolerated in healthy older men and significantly increased the whole-blood levels of NAD + and NAD + -related metabolites

By using a specific VHL-capture-based binding assay, Zhang and colleagues could screen a genome-wide human cDNA library, thus identifying ZHX2 as a new VHL substrate [54]