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Specifically, analyzed were the affected brain areas (04), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), and hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) as follows (score 0 indicates no histopathologic change): score 1: small, patchy, complete, or incomplete infarcts (10% of the area affected)

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A study revealed that in guinea pig models, oral rapamycin-induced mTOR inhibition (even combined with metformin to activate AMPK) exacerbated OA by inducing hyperglycaemia

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