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Furthermore, Rehana et al

Acta Crystallogr D: Biol Crystallogr 67: 756-762

3 The approval of Resmetirom represents a major advancement in MASLD treatment, 4 offering a targeted therapy for patients with progressive MASH and moderate-to-severe liver fibrosis, thereby addressing a longstanding therapeutic gap

On the contrary, the ultra-low doses of LPS induce a trained response and enhance the inflammatory response upon LPS re-stimulation (155, 156)

10.3389/fimmu.2023.1125899

However, protonation at a different site could not only influence thiol pK a values, but additional charge effects could also contribute to the overall reactivity of the molecule (79)