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LTF may not only transmit direct signals upon interaction with mucosal cells, but may also penetrate target organs (55, 89), such as seen after high-systemic oxidative stress (90)

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Ferroptosis of retinal cells, such as RPE, photoreceptor, and RGC, has been reported to be involved in the progression of age-related/inherited macular degeneration, blue light-induced retinal degeneration, glaucoma, DR, and retinal damage caused by retinal IR via multiple molecular mechanisms

More help Relationships Between Two Key Events (Including MIEs and AOs) This table summarizes all of the KERs of the AOP and is populated in the AOP-Wiki as KERs are added to the AOP.Each table entry acts as a link to the individual KER description page

Although GI symptoms are not fatal, these dysfunctions can lead to impaired quality of life in PD patients, affect drug absorption, and cause symptoms fluctuate

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