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10.1016/j.neuron.2006.09.026 94 LeiZ.CaoG.WeiG

F., de Souza, A

Kochar R, Fallon MB

Wallace and colleagues showed in a phase 2B clinical trial that naproxen chemically conjugated with a H 2 S-releasing moiety, ATB-346, inhibits COX-2 as well as naproxen with less gastrointestinal damage than naproxen (ClinicalTrials.gov Identifier: NCT03978208, NCT03291418) [67]

Why it matters: HOMA-IR combines glucose and insulin into a single insulin resistance score

These studies have identified candidate biomarkers and distinct pathophysiologic signatures, which may inform disease classification, risk stratification, and therapeutic targeting [2529]