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Similarly, Tf-LPs loaded with neuroprotective agents such as edaravone, minocycline, and doxycycline have shown promise in neurodegenerative disease research [40, 41]

The end-result of the event is the adherence of the sickle erythrocytes to activated leukocytes immobilized on the endothelium, causing microvascular occlusion, vaso-occlusive crisis (VOC), and tissue ischemia