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A PDX biobank specifically focused on BRAF V600E -mutated gliomas is currently lacking due to the scarcity of patient material, and the difficulty in retrieving complete patients clinical data, pathologies, gene expression profiles, and drug responsiveness ( 3.3 Syngeneic murine models These models are created by implanting an established tumor cell line derived from the same species as the host animal

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Often patients go from pillar to post to see various medical consultants according to specialty (gastroenterologists, dermatologists, etc.), only to discover there isnt one underlying syndrome or root cause that explains all the assorted symptoms the patient is experiencing

J Biol Chem 280:12241229

This review aims to synthesize current research around GPX4