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Description

Weve shown these cells reach the brain intact. Two pathways make this possible: The Olfactory Pathway: Provides rapid, direct access to the brain through extracellular transport, with therapeutic agents reaching the olfactory bulb within minutes of administration

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The final, definitive answer from a human trial is still on the horizon

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The oral route is particularly relevant for gastrointestinal applications because it delivers the peptide directly to the tissues where it is needed

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An in vitro model of the bloodbrain barrier for screening nanomedicine carriers Several cell-based in vitro bloodbrain barrier models have been developed in the past to predict the permeability of nano pharmaceutical formulations to the BBB[206, 207]

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doi: 10.2174/138955711795305335 152

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For decades, its physiological relevance remained speculative, as the peptide had not yet been identified in human tissue

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