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Icotinib also was associated with fewer adverse events than gefitinib when considering all grades of reactions together (61% versus 70% respectively, p = 0.046).[7] The phase IV ISAFE trial evaluated 5,549 patients and showed icotinib to have an overall response rate of 30% and an adverse event rate of 31.5%.[8] This trial demonstrated consistent safety and toxicity profiles of icotinib observed in the ICOGEN trial

In the context of tau pathology, CX has been reported to target 70 key pathways associated with tau-related pathological mechanisms, including interactions with astrocytes, endothelial cells, and microglia

References Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, et al

It is widely used by athletes and active individuals to accelerate recovery from injuries, muscle damage, and joint stress

(2020) 140:182436.e7

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