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Findings from clinical studies also revealed high expression of circulating microRNAs (miRNAs) in the colonic tissues of IBS patients, suggesting the involvement of epigenetic and genetic events in modulating intestinal signaling pathways, particularly serotonin receptor gene with a cis -regulatory variant on the somatic hypersensitivity and intestinal permeability of IBS patients (Kapeller et al., 2008)

[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Wang D.D., Mao Y.Z., He S.M., Yang Y., Chen X

Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines

The receptor profiles are different (dual versus triple agonist), the potency per milligram is different, and the side effect profiles are different

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