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In this study, significant positive correlations were observed between tryptophan, tyrosine, and xanthine abundances in the EWAT and the relative abundance of Parasutterella in the cecal microbiome (Supplementary Table S5, outliers removed)

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Instead of efficiently storing incoming calories as fat, treated adipocytes become more metabolically active, breaking down stored triglycerides and releasing them for energy use

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All mice received 2 days of 10 mL/kg body weight sterile saline subcutaneous injections before beginning the treatment phase to allow for acclimation to the handling and stress associated with injections

These approaches are mechanistically complementary one adds substrate, the other prevents its degradation