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Its efficacy for reducing the amount of time to the first tolerated meal for patients who had undergone either open or laparoscopic bowel resection has been investigated in one phase II clinical trial [6]

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For the ARISTOTLE trial population (apixaban for AF), the dose-reduction criteria require 2.5 mg twice daily when two or more of the following are present: age 80 years or older, body weight 60 kg or less, or serum creatinine 1.5 mg/dL or higher (Granger et al., NEJM 2011) [3]

The same study reported that patients with NAFLD and advanced fibrosis had high levels of GH and low levels of IGF-1 and IGFBP-3 (239)

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