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385 (24): e84

An increase of about 330 calories per day helped to restore the menstrual cycle, and the majority of women experienced improvements after six months of this intervention

Dimaras H, et al

Science 298, 611615

When administered directly into the cerebrospinal fluid of mice, it showed dose-dependent pain-relieving effects that were blocked by naloxone, confirming involvement of opioid pathways