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For patients with neurological involvement, maintenance injections are typically given every 2 months

In many other areas, oral substitution at a sufficiently high dosage has already proven to be equivalent to injections and an improvement of neurological symptoms seems to be equally possible through oral administration (45, 46)

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Standard dosing approach The most commonly cited dosing range is 50 to 150mg per day, typically divided into one to three doses

Macro-B12 should be suspected when a markedly high value persists with no B12 exposure, sits with an unrevealing workup, and disagrees with functional markers

They use it for chronic medical problems or diseases accompanied and complicated by diabetes mellitus