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The IC 50 value of tamoxifen together with 0.4 nM or 1.3 nM of rotenone and rotenone together with tamoxifen (0.15 M or 0.4 M), normalized comparatively using the solvent control were plotted on the resulting graph for each cell line

The gasotransmitters currently identified are NO, hydrogen sulfide (H 2 S), and CO

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Despite all the beneficial effects of IGF-I described up to now and the following ones reporting its role in aging-related pathologies as musculoskeletal, neurodegenerative, cardiovascular diseases, IGF-I has been paradoxically negatively related to lifespan[266, 267], probably due, at least in part, to its downstream molecule Akt and its interactions with FOXO, mTOR and SIRT-1, among others[268, 269]

Preclinical studies show accelerated tendon healing, enhanced collagen synthesis, and improved biomechanical outcomes in animal models

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