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From these many studies, CACNA1C , a gene that codes for the alpha subunit of the L-type voltage-gated Ca ++ channel, has been the most often replicated finding [Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 (20, 33, 34)]

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Active plasma concentrations of flavonolignans range from 50 to 300 ng/mL, with a T max of 68 h, suggesting low and inefficient uptake of flavonolignans

doi: 10.1038/s41467-025-62506-2 115 ChuangSTSteinJBNevinsSKilic BektasCChoiHKKoWKet al

The quality of evidence is limited by small study sizes and lack of large, multicenter trials