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Abstract Nicotinamide adenine dinucleotide (NAD + ) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including nutrient perturbation, genotoxic factors, circadian disorder, infection, inflammation and xenobiotics

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10.1158/1078-0432.CCR-11-1699 79 ModaliS

Clinical evidence indicates that increased Th17/Treg ratios and CD8+ cell infiltration are associated with a decrease in estimated glomerular filtration rate (eGFR) and proteinuria, underscoring their prognostic importance (70)