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Animal Toxicology and/or Pharmacology Preclinical: Intravenous studies in rats with albuterol sulfate have demonstrated that albuterol crosses the blood-brain barrier and reaches brain concentrations amounting to approximately 5% of the plasma concentrations

Small HSPs as first responders to proteotoxic stress In contrast to HSP70 and HSP90, small heat shock proteins do not actively refold misfolded proteins

p53 inhibits ASNS expression by binding to the asparagine synthase (ASNS) gene, decreasing the Asp-Asn ratio, and direct binding of Asp to LKB1 activates AMPK while leading to higher activation of p53 [103]

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[18] While higher levels of homocysteine have been associated with numerous health complications, levels of homocysteine that are too low can also be problematic and have been associated with peripheral neuropathy (often felt as hand and arm tingling) and an impaired ability to make glutathione, an important antioxidant that reduces inflammation in the body

Neuron 2, 15471558 (1989)