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In addition, lactate accumulation can activate gluconeogenesis in liver and skeletal muscle cells, through which lactate is converted to glucose and released into the blood to drive additional glucose consumption during energy expenditure 28

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Several special issues were also addressed, with the panel determining that: management of poison in patients weighing more than 100 kg is the same as that for any acetaminophen product, with the calculation of acetylcysteine dose being capped at 100 kg of body weight