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If you drink too much its bad for your liver, if you smoke too much its bad for your lungs

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Instrumental variable analysis using offspring BMI in childhood as an indicator of parental BMI in relation to mortality Kim Blond, David Carslake, Line Gjrde, Dorte Vistisen, Thorkild Srensen, George Smith, Jennifer Baker Scientific Reports 8

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The striking observation that skeletal muscle dysfunction is likely to manifest before any significant decline in lung function has led to the concept that smoking alone may be sufficient to drive skeletal muscle dysfunction in the absence of COPD (Morse et al., 2007)