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When mitochondrial damage accumulates above a certain threshold, for example in response to energy deprivation, OS, or hypoxia, cells activate a mechanism to selectively target and remove damaged mitochondria via the autophagic machinery to renew the mitochondrial pool (231)

40 MANAGEMENT OF PRIMARY SCLEROSING CHOLANGITIS Medical Management No single drug or treatment has been proven to prolong transplant-free survival in PSC

doi: 10.3389/fresc.2022.1017180, 91

CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer's disease

These differences are likely to reflect monovalent binding of Fab compared with divalent binding of whole IgG, depending upon the spacing of targeted epitopes on the virion surface 94,95,96

Humphries, F