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Gastroenterology 150:13931407 Mitler MM, Gujavarty KS, Browman CP (1982) Maintenance of wakefulness test: a polysomnographic technique for evaluation treatment efficacy in patients with excessive somnolence

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Kinetics and mechanisms of thioldisulfide exchange covering direct substitution and thiol oxidation-mediated pathways

The saturation was noticeably steeper indicating a higher affinity, which was also reflected in the K ITC for the GHGHGHGHG peptide of around 1 M

The tirzepatide shelf life depends on formulation type and storage conditions, and exceeding recommended storage times can result in degraded peptide that does not perform as expected