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In this cell line glutamate induced cytotoxicity could be mediated by oxidative stress through CySS/glutamate antiporter, depletion of GSH, down regulation of SOD activity leading to apoptosis (oxidative glutamate toxicity

Initially used to treat rheumatoid arthritis and multiple sclerosis, DHODH inhibitors were later found helpful in treating cancer, viral infections, and blood disorders [55,56,57,58]

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These compounds commonly reduce oxidative stress and inflammation, enhance the cellular mechanisms for damaged protein clearance, and support neuronal survival and function

The experiments conformed to UK Home Office regulations under the Animals (Scientific Procedures) Act 1986, including Amendment Regulations 2012, and adhered to the Animal Research: Reporting of in Vivo Experiments (ARRIVE) guidelines