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1S10OD025120 for the 10X Chromium housed in the NUSeq Facility, and NIH grant no

Although various studies on copper-induced cell death have shown promising results, there still remain several challenges, such as how the aggregation of fatty acylated proteins triggers cell death, optimizing the performance of copper regulators and reducing their side effects, determining the mode of death induced by copper overload and deficiency, gaining a comprehensive understanding of the roles of copper in the mitochondria, and whether copper ion carriers can selectively deliver drugs to hypertrophic myocardial tissues through drug delivery systems (183)

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Target-specific surface-anchored proteins function by taking up free haem or extracting it from haemoproteins in the extracellular medium and delivering it to a TonB-dependent outer membrane receptor (Hariadi et al., 2015)