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This sets the stage for adverse effects on the body, including chronic disease and illness

3 Case Presentation A 24-year-old woman presented with complaints of unsteady gait, generalized fatigue, and bilateral lower limb swelling lasting for over a week

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These findings suggest that targeting the JAK/STAT axis could provide a dual benefit in HS by attenuating both inflammation and fibrosis, while also addressing the contribution of adipose tissue-derived mediators to these pathogenic mechanisms (Table 2)

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