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Higher rates of mitochondrial biogenesis are needed for neuronal differentiation ( Genetics There have been many observations of links between mtDNA and depression

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In the purine pathway, in addition to uric acid, studies have also identified inosine, an endogenous purine, as capable of downregulating the TNF-, IL-1, IL-6, and Macrophage inflammatory protein-2 (MIP-2) expression induced by LPS, and reducing MIP-1 (Figure 4)