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At the of this articles publication, the U.S

Phytocannabinoids beyond the cannabis plant do they exist

Targeting oncogenic MAGEA6 sensitizes triple negative breast cancer to doxorubicin through its autophagy and ferroptosis by stabling AMPK1

Comparative analysis reveals this duality arises from four mechanistic distinctions ( Figure 5 ): (1) Temporal kineticsexogenous donors produce high peak concentrations with short durations possibly preferentially targeting MDSC redox sensitivity, whereas endogenous enzymes continuously produce H 2 S enabling chronic immune reprogramming

Thus, NRF2-addicted cancers adopt highly specialized metabolism favoring glutathione synthesis that is essential for the potent anti-oxidant and detoxification capacities, which cannot be achieved by a simple activation of NRF2

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