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Cant C, Menzies KJ, Auwerx J (2015) NAD + metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus

In contrast, both TDP-43 and FUS are RNA and DNA binding proteins found predominantly in the nucleus, where they regulate transcription, the DNA response, mRNA splicing, RNA stability, micro-RNA biogenesis, translation and transport, and stress granule formation (Cohen et al., 2019

Within a 68-page briefing document for the committee meeting, the FDAs own experts wrote that there is a lack of evidence to make a conclusion on the effectiveness of BPC-157 for treating ulcerative colitis and there already are FDA-approved drugs available to treat ulcerative colitis, and they proposed not adding BPC-157 to the 503A Bulks List