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We thank Zhe-Sheng (Jason) Chen, (MD., Ph

Emilsson, L., Carlsson, R., Holmqvist, M., James, S

Mico JA, Rojas-Corrales MO, Gibert-Rahola J, Parellada M, Moreno D, Fraguas D et al

More specifically, oral administration is safer than intramuscular injection in animal models because artemisinin is present in experimental animals for a long period after its slow release from intramuscular formulations, leading to severe side effects (Gordi and Lepist, 2004)

In the Sprague-Dawley rat model, PTER improves cholinergic transmission due to the decrease in the activity of acetylcholinesterase and increases the action of ATPases (Na + , K + , Ca 2+ , and Mg 2+ ), which is indicative of the maintenance of the cell membrane potential (Naik et al., 2017)