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With regards to patients with AMD, their mean serum concentration of zinc was found to be significantly lower than that of an age-matched control group

Many patients with PCT, either genetic or acquired, are frequently found to have concurrent HFE gene mutations

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Although a mitochondrial disorder, LHON shares a final common pathway as in other neurodegenerative disorders, namely (RGC-specific) neuronal degeneration and disrupted axonal transport