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doi: 10.7326/0003-4819-118-9-199305010-00004 305 SchmidtBScottIWhitmoreRGFosterHFujimuraSSchmitzJet al

Functional HIF-1 corresponding elements were found in the promoter sequence of the human BNP gene, proving that HIF-1 can induce the activation of the BNP promoter, the transcription of BNP mRNA, and the synthesis and secretion of BNP under hypoxic conditions [90]