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MMPs are thought to contribute to neuroinflammation, oxidative stress, and the disruption of bloodbrain barrier integrity, which are all implicated in PD pathophysiology (Behl et al

Acupunct Res 05:276279 Ma RL, Zhou GM, Zhang R (2009) Restraining effects of acupuncture on photoreceptor cell apoptosis in rats with retinitis pigmentosa induced by N-methyl-N-nitrosourea

Compression therapy may be considered later in selected patients with chronic swelling or venous disease, but it is usually guided carefully and not applied in a way that worsens pain or circulation concerns during acute infection

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Abbreviations CM: Citrulline malate NO: Nitric oxide ATP: Adenosine triphosphate MAS: Malate aspartate shuttle MDH: Malate dehydrogenase NIRS: Near infrared spectroscopy PFK: Phosphofructokinase TCA: Tricarboxylic acid HR: Heart rate GI: Gastrointestinal GVT: German volume training VO 2peak : Peak oxygen consumption EMG: Electromyography References Agudelo LZ, Ferreira DM, Dadvar S, Cervenka I, Ketscher L, Izadi M, Ruas JL (2019) Skeletal muscle PGC-11 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance