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doi: 10.1016/j.jalz.2016.12.001 226

American Journal of Physiology-Gastrointestinal and Live Physiology

Treatment with PARP inhibitors or deletion of PARP1 in mice fed a high-fat diet increased NAD + levels, improved SIRT1 activity and rescued mitochondrial function, thereby protecting the obese mice from insulin resistance [52,53,54]