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Entirely different mechanisms

However, there may be other causes why some people with B12 deficiency require more frequent injections

Reconstitute with bacteriostatic water, inject diluent slowly down the vial wall without shaking, and store at 28C once reconstituted

Pharmacokinetic studies show that after intramuscular injection, hydroxocobalamin is retained in the body longer and lost in the urine less rapidly than cyanocobalamin, producing a more sustained rise in serum cobalamin

For example: Older adults might need more frequent or higher doses because their bodies absorb less and they are more likely to be deficient

Years ago B12 was called maturation factor because cells need B12 to mature from being young and ineffectual whippersnappers to fully functioning, mature cells