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Results: Evidence indicates local estrogen dominance with progesterone resistance, pervasive immune dysregulation, and oxidative stress with iron-driven ferroptosis that particularly injures granulosa cells, alongside disease-relevant genetic/epigenetic regulators and reproductive-tract/gut microbiome dysbiosis

10.1104/pp.109.136630 Plant Physiol

Bauer JL, Kuhn K, Bradford AP, et al

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By mapping thousands of gene changes simultaneously, researchers can understand the broad biological impact of a compound not just one effect, but the entire network of changes it triggers

5) Case examples Dermatology: Customized topical creams (multi-agent formulations not commercially available)